CJC-1295
Also known as: CJC-1295 DAC, CJC-1295 without DAC, Modified GRF 1-29, Mod GRF 1-29
CJC-1295 is a 30-amino-acid peptide analog of growth hormone-releasing hormone (GHRH) that has been modified for extended biological activity. The DAC (Drug Affinity Complex) variant binds to albumin in the bloodstream, extending its half-life to approximately 6-8 days compared to the 30-minute half-life of native GHRH. The non-DAC version, often called Modified GRF 1-29, has a shorter but still enhanced half-life of about 30 minutes. CJC-1295 amplifies GH pulsatility and increases IGF-1 levels, and is frequently stacked with ipamorelin for synergistic growth hormone optimization.
Growing body of research
Well-tolerated with minimal side effects
How It Works
CJC-1295 is a modified GHRH analog with DAC technology extending its half-life. It produces sustained GH and IGF-1 elevation for days after a single injection.
Key Benefits
- Sustained elevation of growth hormone levels
- Increased IGF-1 production
- Enhanced muscle growth and strength
- Improved fat metabolism
- Better deep sleep quality
- Supports bone density and connective tissue health
- Indirect effect to decrease cortisol levels
Who May Benefit
- Adults seeking sustained GH elevation
- Those wanting less frequent dosing
- People combining with Ipamorelin
- Those with age-related GH decline
Dosage & Administration
Expected Timeline
GH elevation within hours. Sleep improvements at 2-3 weeks. Body composition changes over 6-12 weeks.
Safety Information
Possible Side Effects
Contraindications
Dr. Taylor's 2 Cents
“CJC-1295 is the sustained-release partner to ipamorelin. The DAC version gives you steady GH elevation over days, while the non-DAC version (Mod GRF 1-29) provides sharper pulses. I use the non-DAC version combined with ipamorelin for most patients — it's more physiological. This combo is the backbone of my body recomposition and anti-aging protocols.”
Discuss with Dr. Taylor →Frequently Asked Questions
What is CJC-1295 with DAC?
How does it differ from Sermorelin?
How often is it administered?
Can it be used alone?
What results can I expect?
Published Research
Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA · Journal of Clinical Endocrinology & Metabolism (2006)
Key Finding: A single injection of CJC-1295 produced dose-dependent GH increases of 2- to 10-fold lasting 6+ days, and IGF-I increases of 1.5- to 3-fold lasting 9-11 days.
Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone Analog
Ionescu M, Frohman LA · Journal of Clinical Endocrinology & Metabolism (2006)
Key Finding: CJC-1295 preserved natural GH pulsatility while increasing basal GH levels 7.5-fold and IGF-I levels by 45%, indicating physiologically normal stimulation.
Protocols Featuring CJC-1295
Related Reading
Want personalized guidance?
Consult with Dr. Patrick Taylor for a comprehensive evaluation and personalized protocol.
Book a ConsultationMedical Disclaimer: This information is for educational purposes only and is not medical advice. Consult a healthcare provider before starting any peptide protocol.