Tissue RepairEmerging ResearchResearch Only

TB-500

Also known as: Thymosin Beta-4, TB4, Timbetasin

TB-500 is a synthetic peptide that replicates the active region of thymosin beta-4, a 43-amino-acid protein produced naturally by the thymus gland. It plays a central role in actin regulation, cell migration, and new blood vessel formation, all critical processes for tissue repair. TB-500 has been shown to promote healing of muscles, tendons, and skin while reducing inflammation and scar tissue formation. Its systemic activity means it can travel through the bloodstream to locate and promote repair at injury sites throughout the body.

Research Score6/10

Growing body of research

Safety Score8/10

Well-tolerated with minimal side effects

How It Works

TB-500 upregulates cell-building proteins like actin for cell migration and proliferation. It promotes angiogenesis, reduces inflammation, and supports tissue remodeling.

Key Benefits

  • Promotes wound healing and tissue regeneration
  • Reduces inflammation and fibrosis
  • Improves flexibility and range of motion
  • Supports cardiac tissue repair
  • Enhances hair regrowth in some individuals
  • Accelerates recovery from muscle injuries

Who May Benefit

  • Athletes with chronic or acute musculoskeletal injuries
  • Individuals with slow-healing wounds
  • People with inflammatory conditions
  • Those seeking enhanced flexibility

Dosage & Administration

Typical Dosage
One to two times daily, 3 to 5 times weekly
Cycle Length
4-12 weeks
Administration Routes
subcutaneous

Expected Timeline

Anti-inflammatory effects in 1-2 weeks. Tissue repair at 4-6 weeks. Full cycle of 8-12 weeks recommended.

Safety Information

Possible Side Effects

Head rush or lightheadedness shortly after injectionInjection site redness or irritationTemporary fatigueMild nausea

Contraindications

Active cancer or history of malignancyPregnancy or breastfeedingChildren and adolescents
Dr. Patrick Taylor, MD

Dr. Taylor's 2 Cents

“TB-500 is my second favorite repair peptide. I typically pair it with BPC-157 for synergistic healing — they hit different pathways. TB-500 excels at systemic repair because it's small enough to travel through the bloodstream to find injury sites. Great for athletes and patients with chronic injuries that haven't responded to conventional treatment.”

Discuss with Dr. Taylor →

Frequently Asked Questions

What is TB-500?
A synthetic version of Thymosin Beta-4, involved in tissue repair and regeneration.
How does TB-500 differ from BPC-157?
TB-500 upregulates actin and promotes cell migration; BPC-157 focuses on growth factors. Often used together.
What is the typical dosage?
Loading phase: 4-8 mg/week for 4-6 weeks, then maintenance of 2-4 mg/week.
Is TB-500 legal?
Available through compounding pharmacies with prescription. Not FDA-approved. Banned by WADA.
What side effects can occur?
Generally well-tolerated. Possible temporary lethargy, head rush, injection site irritation.
How long should I take TB-500?
Typical cycles are 8-12 weeks with periodic breaks.

Published Research

1

Thymosin beta4 accelerates wound healing

Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK · Journal of Investigative Dermatology (1999)

Key Finding: Thymosin beta-4 increased re-epithelialization by 42% at 4 days and up to 61% at 7 days versus controls, with increased collagen deposition and angiogenesis.

PubMed →DOI →
2

The regenerative peptide thymosin beta4 accelerates the rate of dermal healing in preclinical animal models and in patients

Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL · Annals of the New York Academy of Sciences (2012)

Key Finding: Thymosin beta-4 accelerated dermal healing in multiple animal models and two Phase 2 clinical trials for ulcers, accelerating healing by nearly one month in patients who healed.

PubMed →DOI →

Protocols Featuring TB-500

Recovery & Repair Protocol
Accelerate healing from injuries and surgery
Skin & Hair Renewal Protocol
Collagen, elastin, and follicle support

Related Peptides

BPC-157
Tissue Repair
GHK-Cu
Skin & Hair

Related Reading

A Beginner's Guide to Peptide Therapy
Everything you need to know about therapeutic peptides, how they work, and what to expect when starting peptide therapy.
BPC-157: The Complete Evidence-Based Guide
An in-depth look at BPC-157, one of the most versatile healing peptides, including benefits, dosage protocols, and current research.
The Wolverine Stack: BPC-157 + TB-500 Recovery Guide
The most popular peptide combination for injury recovery. Learn how the Wolverine Stack works, dosage protocols, and what to expect.
The Gut Healing Stack: BPC-157, KPV & LL-37 for Digestive Health
A physician's guide to the gut healing peptide stack. How BPC-157, KPV, and LL-37 work together to repair, calm, and rebalance your digestive system.

Want personalized guidance?

Consult with Dr. Patrick Taylor for a comprehensive evaluation and personalized protocol.

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Medical Disclaimer: This information is for educational purposes only and is not medical advice. Consult a healthcare provider before starting any peptide protocol.